BIOESTIMULANTES DE COLÁGENO NO REJUVENESCIMENTO FACIAL

Abstract

Skin aging, characterized by sagging, wrinkles, and loss of volume, has driven the search for effective and less invasive aesthetic treatments. Emerging alternatives include collagen biostimulators, injectable substances that promote neocollagenesis and restore skin firmness and elasticity. This study aims to analyze the main biostimulators used in facial rejuvenation — such as poly-L-lactic acid, calcium hydroxyapatite, and polycaprolactone — evaluating their mechanisms of action, efficacy, aesthetic applications,safety, and limitations. The methodology adopted was an integrative literature review, with a bibliographic survey in databases such as SCIELO, LILACS, PUBMED, and Google Scholar, from 2018 to 2025, including articles in Portuguese, English, and Spanish. Twenty studies that directly addressed biostimulators in the context of facial rejuvenation were selected. The data were organized into files and submitted to content analysis. The results indicate that biostimulators have progressive and natural aesthetic effects, with significant improvement in skin quality and a high patient satisfaction rate. In addition to promoting firmness and volume, they are indicated for various regions of the face and extrafacial areas. Adverse effects are generally mild and temporary, as long as the procedure is performed by trained professionals. It is concluded that collagen biostimulators represent a safe, effective and long-lasting alternative for facial rejuvenation, integrating a modern and personalized aesthetic approach. The research reinforces the importance of well-defined clinical criteria for choosing the biostimulator, aiming to maximize benefits and minimize risks. In-depth comparative and long-term clinical studies are suggested to better understand the impacts and potential of this technique