EFEITOS DO ÁCIDO VALPROICO NA GESTAÇÃO: RISCO DE TRANSTORNO DO ESPECTRO AUTISTA

Abstract

Autism is a neurodevelopmental disorder characterized by difficulties in social interaction, communication, and isolation, with signs that appear in childhood. Although genetic factors are associated with autism, the environmental factor also plays a very important role. The use of valproic acid (VA) during pregnancy, especially in the third trimester, a critical phase for the formation of the central nervous system, is associated with a higher risk of developing autism spectrum disorders in the fetus. VA is an anticonvulsant that acts on the central nervous system, but it has strong teratogenic potential, being able to cross the placental barrier and affect neurodevelopment. International guidelines recommend caution when prescribing this medication to pregnant women. This study aims to analyze the effects of VA in the induction of autism and to suggest safer therapeutic alternatives during pregnancy