HERDA (ASTENIA DÉRMICA REGIONAL EQUINA HEREDITÁRIA) – RELATO DE CASO

Abstract

Hereditary Equine Regional Dermal Asthenia (HERDA) is an autosomal recessive disorder caused by a mutation in the peptidyl-prolyl isomerase B (PPIB) gene, which is responsible for collagen synthesis and modification. The condition primarily affects Quarter Horses and is characterized by pathognomonic clinical signs, including skin hyperextensibility, fragility, and impaired wound healing. Diagnosis can be established through clinical and histopathological findings, genetic testing, and pedigree analysis, which reveal that affected or carrier animals share a genetic lineage with the stallion Poco Bueno (1944–1969). The prognosis ranges from guarded to unfavorable, with almost all affected animals being euthanized; however, in some cases, palliative treatment may be performed. Therefore, this paper reports the evolution of a clinical case of a Quarter Horse that tested positive for the disease and underwent palliative treatment in a municipality in the interior of Goiás. Furthermore, it aims to promote the dissemination of information and updates about this disease, alerting professionals in the field about its spread, emphasizing the importance of genetic selection; clinical signs, diagnosis, prognosis, prevention, and consequences for equine breeding.